The loss was the joint-heaviest defeat by a side already crowned Premier League champions. Arsenal were beaten 4-0 at Liverpool in 1997-98 in the game after they clinched the title.
Manchester City survived a stirring Leicester City fightback to claim a 2-1 win that lifted them above Liverpool into third in the Premier League on Saturday.
Manchester City have dominated English football in recent years under Pep Guardiola, although they finished second to Liverpool in the Premier League this season, but have yet to add Europe's most coveted prize to their trophy cabinet.
Barcelona's Lionel Messi is the best player ever, Bayern coach Pep Guardiola said.
Klopp and his City counterpart Pep Guardiola were satisfied with their team's displays in a tight, tactical encounter which finished 0-0 at Anfield, but the German was clearly frustrated to now lose his players for international duty.
Manchester City tightened their stranglehold at the top of the Premier League on Wednesday by trouncing bottom club West Bromwich Albion 3-0 as nearest rivals Manchester United suffered a chastening 2-0 defeat at Tottenham Hotspur.
Before the game, a few protesters handed out fliers outside the stadium where Man City played local outfit Kitchee.
The 55-year-old Ernesto Valverde, who led Barcelona to successive La Liga titles in 2018 and 2019, came under fire this season for the team's dip in performance levels even though they top the league standings at the halfway point of the campaign.
Real Madrid fought back from the brink of elimination to beat Manchester City 3-1 after extra time and 6-5 on aggregate in an enthralling and dramatic Champions League semi-final on Wednesday.
Their work in the transfer market has also added to the positivity around the club after German manager Juergen Klopp made some major moves that have clearly strengthened his squad.
Toure criticises players for accepting lure of China cash
Whatever happens, there will be no shortage of drama between now and May 12.
Manchester City striker Gabriel Jesus failed to find the net in over 700 minutes on the pitch in a run of 10 games between October and November for club and country, as City struggled to keep pace in the Premier League title race and dropped to third. Jesus is City's second-choice striker behind Sergio Aguero and he had admitted to being frustrated earlier this season when Pep Guardiola benched him in favour of the Argentine.
The goal machines of Bayern Munich, Chelsea and Shakhtar Donetsk cranked into top gear on Tuesday as the Champions League captivated its continental audience with a record 40 goals in one eight-game night.
Manchester United manager Jose Mourinho has promised to show plenty of restraint and respect if he inflicts a first Premier League defeat of the season on his former side Chelsea on Saturday.
"Sergio Aguero will be assessed by Club doctors today after being involved in a road accident on Thursday," City said of the Argentina striker in a statement on their website. (www.mancity.com)
Images from the English Premier League matches played on Saturday.
Premier League leaders City said a statue will be erected outside the Etihad Stadium in the Argentine's honour, alongside those of his former team mates David Silva and Vincent Kompany.
European champions Liverpool are second in their Champions League group - a point behind Napoli - and Klopp's side host Genk at Anfield.
Four players tested positive for coronavirus in the latest batch of tests conducted by the English Premier League and announced on Wednesday. Russian Premier League club Lokomotiv Moscow said on Thursday that four of its players had tested positive for the novel coronavirus.
A summary of Sunday's action in the Premier League.
Manchester United manager Jose Mourinho said the international break has made his plans for the Manchester derby a bit more 'complicated' than he would have liked, especially with his South American players returning a day before the clash.
IMAGES from the English Premier League matches played on Wednesday.
Manchester City showed that their weekend derby loss was a blip as Kevin de Bruyne and Riyad Mahrez both scored twice in a 5-2 win over Southampton
England's League Managers' Association has revealed that the average tenure of a Premier League manager is now little more than two seasons, with 11 of last year's 20 starters already kicked out.
Attack is the best form of defence for Manchester City boss Pep Guardiola.
IMAGES from the English Premier League matches played on Saturday.
Images from Wednesday's Champions League matches, between Real Madrid and Paris St Germain, and Manchester City and Sporting CP
Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable:
Nolito is adamant that he will not allow growing speculation about his club future to become a distraction as he "lives a dream" with Spain at Euro 2016.
A summary of Saturday's action in the Premier League.
Images from Saturday's action in the English Premier League.
Liverpool moved to 76 points from 32 games with title rivals Manchester City on 74 points from one game fewer, with Pep Guardiola's side hosting Brighton and Hove Albion at the Etihad on Wednesday.
Bundesliga leaders Bayern Munich were made to work extremely hard for a 3-1 victory at VfB Stuttgart on Saturday that sent them eight points clear at the top of the table with five games left.
Manchester City's midfield powerhouse Yaya Toure will leave the club at the end of the season having not been offered a new contract, his agent said on Monday.
Manchester City blew a two-goal lead and had Ederson sent off in a dramatic 3-2 defeat at Wolves on Friday.
Manchester City moved back to second in the Premier League after a stylish 3-0 win over Everton at the Etihad Stadium on Sunday as Pep Guardiola's side responded to convincing Chelsea and Liverpool wins with a reminder of their class.
UEFA had banned City from European competition for two years after ruling they had breached Financial Fair Play (FFP) regulations but City won an appeal last month to have that verdict and sanction overturned.
Manchester United should sack Louis Van Gaal and install his assistant Ryan Giggs as manager, according to former striker Dwight Yorke who wants to launch his own managerial career at struggling Aston Villa. The former Trinidad and Tobago striker said changes were needed at United, with the 20-times English champions sixth in the Premier League, out of the Champions League and suffering a 2-0 loss to arch-rivals Liverpool in the Europa League this week. "At the end of the day, it's all about results," Yorke was quoted as saying by Singaporean daily The New Paper on Saturday after a promotional event in the Southeast Asian citystate. "In the two years that he's (Van Gaal) been there, he's spent tons of money, brought in tons of players, and simply hasn't got the results that he and everyone else had hoped to. "You see a lot of young managers, Zinedine Zidane's been given the opportunity at Real Madrid, you got Luis Enrique at Barcelona, Pep Guardiola who's coming to Manchester City, Tottenham's Mauricio Pochettino, they're all ex-players. "And I feel that the game is going down that road, and maybe this is the right time to give Giggsy the job." Yorke won three Premier League titles and the 1999 Champions League with United under former manager Alex Ferguson after joining from Aston Villa.
Roundup of Champions League matches played on Wednesday night